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essential oil is mainly used in the cosmetics and perfumery industry, but it also finds application in the food industry as a flavoring agent. In addition, different processes of evolution of the prefibrillar aggregates have also been identified, suggesting that the nucleation processes diversify depending on the polymorphism of amyloid fibrils. Detailed investigations at pH 5.2 in comparison with those at pH 8.7 have suggested that the evolution of protofibril-like aggregates is a common mechanism. In particular, different structures of amyloid fibrils were found at pH 5.2 and pH 8.7, making it possible to compare different pathways. The B chain showed strong propensity to form amyloid fibrils over a wide pH range, and prefibrillar aggregates were formed under all examined conditions. Here, we have investigated the formation of insulin B chain amyloid fibrils under different pH conditions to better understand amyloid nucleation mediated by prefibrillar aggregates. With this situation, we have previously identified prefibrillar aggregates in the formation of insulin B chain amyloid fibrils, which have provided an insight into the mechanisms of protein assembly involved in nucleation. The formation of amyloid fibrils is typically initiated by nucleation, whereas its exact mechanisms are largely unknown. Companion journals for Molecules include: Foundations and Photochem.Īmyloid fibrils have been an important subject as they are involved in the development of many amyloidoses and neurodegenerative diseases.Testimonials: See what our editors and authors say about Molecules.Sections: published in 26 topical sections.Recognition of Reviewers: reviewers who provide timely, thorough peer-review reports receive vouchers entitling them to a discount on the APC of their next publication in any MDPI journal, in appreciation of the work done.This journal in the second half of 2021). To publication is undertaken in 2.9 days (median values for papers published in Rapid Publication: manuscripts are peer-reviewed and a firstĭecision provided to authors approximately 14.6 days after submission acceptance.Journal Rank: JCR - Q2 ( Chemistry, Multidisciplinary) / CiteScore - Q1 ( Chemistry (miscellaneous)).High Visibility: indexed within Scopus, SCIE (Web of Science), PubMed, MEDLINE, PMC, Reaxys, Embase, CaPlus / SciFinder, AGRIS, and many other databases.
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